New Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphne

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dc.contributor.authorHirayama, Yuichiroen
dc.contributor.authorKatavic, Peter L.en
dc.contributor.authorWhite, Andrew M.en
dc.contributor.authorPierens, Gregory K.en
dc.contributor.authorLambert, Lynette K.en
dc.contributor.authorWinters, Anne E.en
dc.contributor.authorKigoshi, Hideoen
dc.contributor.authorKita, Masakien
dc.contributor.authorGarson, Mary J.en
dc.date.accessioned2025-12-16T19:40:43Z
dc.date.available2025-12-16T19:40:43Z
dc.date.issued2016en
dc.description.abstractThis study reports the isolation and characterisation of six new metabolites with 'gracilin'-type carbon skeletons and of aplytandiene-3 from the Australian nudibranch Goniobranchus splendidus. The structure of gracilin G is revised, and the C-6 configuration deduced by comparison of calculated 3JC/H values with values measured using the EXSIDE pulse sequence. A lactone isolated from Goniobranchus daphne contains a rearranged spongionellin-type skeleton. Screening of selected metabolites revealed significant cytotoxicity against a HeLa S3 cell line by five of the new terpenes.en
dc.description.statusPeer-revieweden
dc.format.extent9en
dc.identifier.issn0004-9425en
dc.identifier.otherORCID:/0000-0002-9481-1079/work/167652636en
dc.identifier.scopus84957561255en
dc.identifier.urihttps://hdl.handle.net/1885/733795546
dc.language.isoenen
dc.rightsPublisher Copyright: © CSIRO 2016.en
dc.sourceAustralian Journal of Chemistryen
dc.titleNew Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphneen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage144en
local.bibliographicCitation.startpage136en
local.contributor.affiliationHirayama, Yuichiro; University of Tsukubaen
local.contributor.affiliationKatavic, Peter L.; University of Queenslanden
local.contributor.affiliationWhite, Andrew M.; School of Chemistry and Molecular Biosciencesen
local.contributor.affiliationPierens, Gregory K.; University of Queenslanden
local.contributor.affiliationLambert, Lynette K.; University of Queenslanden
local.contributor.affiliationWinters, Anne E.; University of Queenslanden
local.contributor.affiliationKigoshi, Hideo; University of Tsukubaen
local.contributor.affiliationKita, Masaki; University of Tsukubaen
local.contributor.affiliationGarson, Mary J.; University of Queenslanden
local.identifier.citationvolume69en
local.identifier.doi10.1071/CH15203en
local.identifier.pure015b558c-7d1d-4a9f-b339-f5b7b03bf412en
local.identifier.urlhttps://www.scopus.com/pages/publications/84957561255en
local.type.statusPublisheden

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