Uncovering an IS-PC2ET Mechanism that Facilitates I(III)-to-I(V) Oxidation

Abstract

Proton-coupled electron transfer (PCET) plays a central role in oxidative iodine chemistry. In this study, we show that 2-iodobenzoic acid (1) is readily oxidized by Oxone to generate the I(V) species IBX, while 2-iodo-1,3-benzenedicarboxylic acid (8) is only oxidized to the I(III) species iodosodilactone (12). Density functional theory (DFT) calculations reveal that the oxidation of both substrates follows an inner-sphere two-electron transfer (IS-2ET) mechanism, in which push–pull interactions facilitate the process. While the initial I(I)-to-I(III) step proceeds with comparable activation barriers for both 1 and 8, the subsequent I(III)-to-I(V) oxidation is significantly less favorable for 8, with a barrier of 44.9 kcal/mol compared to 24.7 kcal/mol for 1. For compound 1, oxidation proceeds via an I(III) intermediate, iodosobenzoic acid (IBA), bearing an OH ligand. We found that IBA is oxidized to IBX with a moderate activation barrier when the reaction proceeds via an inner-sphere proton-coupled two-electron transfer (IS-PC2ET), in which deprotonation of the OH group precedes two-electron transfer to Oxone. In contrast, compound 12 lacks an OH ligand and cannot undergo IS-PC2ET, rendering further oxidation inaccessible. These findings reveal a distinct subclass of PCET mechanisms and provide guiding principles for designing iodine-based oxidants capable of accessing the I(V) state under mild conditions. Show more