Studies in macrolide synthesis: Stereocontrolled synthesis of a C<sub>1</sub>-C<sub>13</sub> segment of concanamycin A

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Paterson, Ian
McLeod, Malcolm D.

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The C1-C13 segment 6 of concanamycin A (1) was prepared by a highly stereocontrolled route (87% overall ds) in 16 steps from the ester 9. Key steps are the one-pot aldol/reduction, 8 → 12, and the HWE reaction, 18 + 19 → 6.

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Tetrahedron Letters

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