Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis
| dc.contributor.author | Csuk, René | en |
| dc.contributor.author | Sczepek, Ronny | en |
| dc.contributor.author | Siewert, Bianka | en |
| dc.contributor.author | Nitsche, Christoph | en |
| dc.date.accessioned | 2025-05-23T19:31:23Z | |
| dc.date.available | 2025-05-23T19:31:23Z | |
| dc.date.issued | 2013-01-15 | en |
| dc.description.abstract | Several novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death. | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 11 | en |
| dc.identifier.issn | 0968-0896 | en |
| dc.identifier.other | PubMed:23245801 | en |
| dc.identifier.other | ORCID:/0000-0002-3704-2699/work/162948551 | en |
| dc.identifier.scopus | 84871629620 | en |
| dc.identifier.uri | http://www.scopus.com/inward/record.url?scp=84871629620&partnerID=8YFLogxK | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733753052 | |
| dc.language.iso | en | en |
| dc.source | Bioorganic and Medicinal Chemistry | en |
| dc.subject | Annexin V assay | en |
| dc.subject | Antitumor | en |
| dc.subject | Apoptosis | en |
| dc.subject | Betulin | en |
| dc.subject | Cancer | en |
| dc.subject | DNA laddering | en |
| dc.subject | Hydroxypropargylamines | en |
| dc.subject | Mannich reaction | en |
| dc.subject | SRB assay | en |
| dc.title | Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis | en |
| dc.type | Journal article | en |
| dspace.entity.type | Publication | en |
| local.bibliographicCitation.lastpage | 435 | en |
| local.bibliographicCitation.startpage | 425 | en |
| local.contributor.affiliation | Csuk, René; Martin Luther University Halle-Wittenberg | en |
| local.contributor.affiliation | Sczepek, Ronny; Martin Luther University Halle-Wittenberg | en |
| local.contributor.affiliation | Siewert, Bianka; Martin Luther University Halle-Wittenberg | en |
| local.contributor.affiliation | Nitsche, Christoph; Bereich Organische Chemie | en |
| local.identifier.citationvolume | 21 | en |
| local.identifier.doi | 10.1016/j.bmc.2012.11.016 | en |
| local.identifier.pure | 258a46ec-010e-4a07-9176-c46b195ffc7e | en |
| local.identifier.url | https://www.scopus.com/pages/publications/84871629620 | en |
| local.type.status | Published | en |