Cultural advice

The Australian National University acknowledges, celebrates and pays our respects to the Ngunnawal and Ngambri people of the Canberra region and to all First Nations Australians on whose traditional lands we meet and work, and whose cultures are among the oldest continuing cultures in human history.

Aboriginal and Torres Strait Islander peoples are advised that ANU Library collections may include images, names, voices, and other representations of deceased persons.

Material in the collection may contain terms, language or views that reflect the period in which the item was created and may be considered inappropriate today.

Cytotoxic betulin-derived hydroxypropargylamines trigger apoptosis

Simple item page
dc.contributor.authorCsuk, Renéen
dc.contributor.authorSczepek, Ronnyen
dc.contributor.authorSiewert, Biankaen
dc.contributor.authorNitsche, Christophen
dc.date.accessioned2025-05-23T19:31:23Z
dc.date.available2025-05-23T19:31:23Z
dc.date.issued2013-01-15en
dc.description.abstractSeveral novel betulin derivatives were prepared and evaluated for their antitumor activity. Among others, 3-O-acetylbetulinic aldehyde served as an ideal starting material for the synthesis of 28-acetylenic derivatives that were further transformed into Mannich bases. These hydroxypropargylamines were screened for their antitumor activity in a panel of nine human cancer cell lines in a sulforhodamine B (SRB) assay. Several compounds showed a noteworthy antitumor activity. The results from acridine orange/propidium iodide staining and annexinV-FITC assays as well as DNA laddering experiments provided evidence for an apoptotic cell death.en
dc.description.statusPeer-revieweden
dc.format.extent11en
dc.identifier.issn0968-0896en
dc.identifier.otherPubMed:23245801en
dc.identifier.otherORCID:/0000-0002-3704-2699/work/162948551en
dc.identifier.scopus84871629620en
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84871629620&partnerID=8YFLogxKen
dc.identifier.urihttps://hdl.handle.net/1885/733753052
dc.language.isoenen
dc.sourceBioorganic and Medicinal Chemistryen
dc.subjectAnnexin V assayen
dc.subjectAntitumoren
dc.subjectApoptosisen
dc.subjectBetulinen
dc.subjectCanceren
dc.subjectDNA ladderingen
dc.subjectHydroxypropargylaminesen
dc.subjectMannich reactionen
dc.subjectSRB assayen
dc.titleCytotoxic betulin-derived hydroxypropargylamines trigger apoptosisen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage435en
local.bibliographicCitation.startpage425en
local.contributor.affiliationCsuk, René; Martin Luther University Halle-Wittenbergen
local.contributor.affiliationSczepek, Ronny; Martin Luther University Halle-Wittenbergen
local.contributor.affiliationSiewert, Bianka; Martin Luther University Halle-Wittenbergen
local.contributor.affiliationNitsche, Christoph; Bereich Organische Chemieen
local.identifier.citationvolume21en
local.identifier.doi10.1016/j.bmc.2012.11.016en
local.identifier.pure258a46ec-010e-4a07-9176-c46b195ffc7een
local.identifier.urlhttps://www.scopus.com/pages/publications/84871629620en
local.type.statusPublisheden

Downloads

Collections

ANU Research Publications

DSpace software copyright © 2002-2026 LYRASIS