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A computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductants

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dc.contributor.authorEjehi, Zeinaben
dc.contributor.authorAriafard, Alirezaen
dc.date.accessioned2025-06-11T14:39:28Z
dc.date.available2025-06-11T14:39:28Z
dc.date.issued2017en
dc.description.abstractIt is widely reported that the Pt(iv) prodrugs with two axial chlorido ligands are reduced by biological reductants via a chloride-bridged inner-sphere mechanism. By contrast, in this contribution, we demonstrate that although this approach might be true for the reductants with sulphur donors, the reduction by ascorbates preferentially occurs via an outer sphere mechanism.en
dc.description.statusPeer-revieweden
dc.format.extent4en
dc.identifier.issn1359-7345en
dc.identifier.otherPubMed:28079213en
dc.identifier.otherORCID:/0000-0003-2383-6380/work/163628651en
dc.identifier.scopus85010297188en
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85010297188&partnerID=8YFLogxKen
dc.identifier.urihttps://hdl.handle.net/1885/733758705
dc.language.isoenen
dc.rightsPublisher Copyright: © The Royal Society of Chemistry 2017.en
dc.sourceChemical Communicationsen
dc.titleA computational mechanistic investigation into the reduction of Pt(IV) prodrugs with two axial chlorides by biological reductantsen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage1416en
local.bibliographicCitation.startpage1413en
local.contributor.affiliationEjehi, Zeinab; Islamic Azad Universityen
local.contributor.affiliationAriafard, Alireza; Department of Chemistryen
local.identifier.citationvolume53en
local.identifier.doi10.1039/c6cc07834fen
local.identifier.pure0ff5d788-4159-4990-8613-1588e8530cbaen
local.identifier.urlhttps://www.scopus.com/pages/publications/85010297188en
local.type.statusPublisheden

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