Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes
| dc.contributor.author | Meucci, Elizabeth A. | en |
| dc.contributor.author | Nguyen, Shay N. | en |
| dc.contributor.author | Camasso, Nicole M. | en |
| dc.contributor.author | Chong, Eugene | en |
| dc.contributor.author | Ariafard, Alireza | en |
| dc.contributor.author | Canty, Allan J. | en |
| dc.contributor.author | Sanford, Melanie S. | en |
| dc.date.accessioned | 2025-12-16T21:40:55Z | |
| dc.date.available | 2025-12-16T21:40:55Z | |
| dc.date.issued | 2019-08-14 | en |
| dc.description.abstract | This Article describes the development of a stable NiIV complex that mediates C(sp2)-H trifluoromethylation reactions. This reactivity is first demonstrated stoichiometrically and then successfully translated to a NiIV-catalyzed C-H trifluoromethylation of electron-rich arene and heteroarene substrates. Both experimental and computational mechanistic studies support a radical chain pathway involving NiIV, NiIII, and NiII intermediates. | en |
| dc.description.sponsorship | This work was supported by the National Science Foundation (NSF) Grant CHE-1111563, the Australian Research Council, and the Australian National Computing Infrastructure. We also thank Rackham Graduate School and the NSF for graduate fellowships to E.A.M., the NSF for a REU summer fellowship for S.N.N., and the NSERC for a postdoctoral fellowship for E.C. We gratefully acknowledge Dr. Jeff Kampf for X-ray crystallographic analysis of complex II , as well as funding from NSF Grant CHE-0840456 for X-ray instrumentation. | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 8 | en |
| dc.identifier.issn | 0002-7863 | en |
| dc.identifier.other | PubMed:31379153 | en |
| dc.identifier.other | ORCID:/0000-0003-2383-6380/work/197987412 | en |
| dc.identifier.scopus | 85071002612 | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733795598 | |
| dc.language.iso | en | en |
| dc.rights | © 2019 The Authors | en |
| dc.source | Journal of the American Chemical Society | en |
| dc.title | Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes | en |
| dc.type | Journal article | en |
| dspace.entity.type | Publication | en |
| local.bibliographicCitation.lastpage | 12879 | en |
| local.bibliographicCitation.startpage | 12872 | en |
| local.contributor.affiliation | Meucci, Elizabeth A.; University of Michigan, Ann Arbor | en |
| local.contributor.affiliation | Nguyen, Shay N.; University of Michigan, Ann Arbor | en |
| local.contributor.affiliation | Camasso, Nicole M.; University of Michigan, Ann Arbor | en |
| local.contributor.affiliation | Chong, Eugene; University of Michigan, Ann Arbor | en |
| local.contributor.affiliation | Ariafard, Alireza; School of Physical Sciences | en |
| local.contributor.affiliation | Canty, Allan J.; University of Tasmania | en |
| local.contributor.affiliation | Sanford, Melanie S.; University of Michigan, Ann Arbor | en |
| local.identifier.citationvolume | 141 | en |
| local.identifier.doi | 10.1021/jacs.9b06383 | en |
| local.identifier.pure | e875ff19-2fb0-4d81-b4f2-d8c17604f6f9 | en |
| local.identifier.url | https://www.scopus.com/pages/publications/85071002612 | en |
| local.type.status | Published | en |