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Nickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenes

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dc.contributor.authorMeucci, Elizabeth A.en
dc.contributor.authorNguyen, Shay N.en
dc.contributor.authorCamasso, Nicole M.en
dc.contributor.authorChong, Eugeneen
dc.contributor.authorAriafard, Alirezaen
dc.contributor.authorCanty, Allan J.en
dc.contributor.authorSanford, Melanie S.en
dc.date.accessioned2025-12-16T21:40:55Z
dc.date.available2025-12-16T21:40:55Z
dc.date.issued2019-08-14en
dc.description.abstractThis Article describes the development of a stable NiIV complex that mediates C(sp2)-H trifluoromethylation reactions. This reactivity is first demonstrated stoichiometrically and then successfully translated to a NiIV-catalyzed C-H trifluoromethylation of electron-rich arene and heteroarene substrates. Both experimental and computational mechanistic studies support a radical chain pathway involving NiIV, NiIII, and NiII intermediates.en
dc.description.sponsorshipThis work was supported by the National Science Foundation (NSF) Grant CHE-1111563, the Australian Research Council, and the Australian National Computing Infrastructure. We also thank Rackham Graduate School and the NSF for graduate fellowships to E.A.M., the NSF for a REU summer fellowship for S.N.N., and the NSERC for a postdoctoral fellowship for E.C. We gratefully acknowledge Dr. Jeff Kampf for X-ray crystallographic analysis of complex II , as well as funding from NSF Grant CHE-0840456 for X-ray instrumentation.en
dc.description.statusPeer-revieweden
dc.format.extent8en
dc.identifier.issn0002-7863en
dc.identifier.otherPubMed:31379153en
dc.identifier.otherORCID:/0000-0003-2383-6380/work/197987412en
dc.identifier.scopus85071002612en
dc.identifier.urihttps://hdl.handle.net/1885/733795598
dc.language.isoenen
dc.rights© 2019 The Authorsen
dc.sourceJournal of the American Chemical Societyen
dc.titleNickel(IV)-Catalyzed C-H Trifluoromethylation of (Hetero)arenesen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage12879en
local.bibliographicCitation.startpage12872en
local.contributor.affiliationMeucci, Elizabeth A.; University of Michigan, Ann Arboren
local.contributor.affiliationNguyen, Shay N.; University of Michigan, Ann Arboren
local.contributor.affiliationCamasso, Nicole M.; University of Michigan, Ann Arboren
local.contributor.affiliationChong, Eugene; University of Michigan, Ann Arboren
local.contributor.affiliationAriafard, Alireza; School of Physical Sciencesen
local.contributor.affiliationCanty, Allan J.; University of Tasmaniaen
local.contributor.affiliationSanford, Melanie S.; University of Michigan, Ann Arboren
local.identifier.citationvolume141en
local.identifier.doi10.1021/jacs.9b06383en
local.identifier.puree875ff19-2fb0-4d81-b4f2-d8c17604f6f9en
local.identifier.urlhttps://www.scopus.com/pages/publications/85071002612en
local.type.statusPublisheden

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