Genome-wide patterns of selection in 230 ancient Eurasians

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dc.contributor.authorMathieson, Iainen
dc.contributor.authorLazaridis, Iosifen
dc.contributor.authorRohland, Nadinen
dc.contributor.authorMallick, Swapanen
dc.contributor.authorPatterson, Nicken
dc.contributor.authorRoodenberg, Songül Alpaslanen
dc.contributor.authorHarney, Eadaoinen
dc.contributor.authorStewardson, Kristinen
dc.contributor.authorFernandes, Danielen
dc.contributor.authorNovak, Marioen
dc.contributor.authorSirak, Kendraen
dc.contributor.authorGamba, Cristinaen
dc.contributor.authorJones, Eppie R.en
dc.contributor.authorLlamas, Bastienen
dc.contributor.authorDryomov, Stanislaven
dc.contributor.authorPickrell, Josephen
dc.contributor.authorArsuaga, Juan Luísen
dc.contributor.authorDe Castro, José María Bermúdezen
dc.contributor.authorCarbonell, Eudalden
dc.contributor.authorGerritsen, Fokkeen
dc.contributor.authorKhokhlov, Aleksandren
dc.contributor.authorKuznetsov, Pavelen
dc.contributor.authorLozano, Marinaen
dc.contributor.authorMeller, Haralden
dc.contributor.authorMochalov, Olegen
dc.contributor.authorMoiseyev, Vyacheslaven
dc.contributor.authorGuerra, Manuel A.Rojoen
dc.contributor.authorRoodenberg, Jacoben
dc.contributor.authorVergès, Josep Mariaen
dc.contributor.authorKrause, Johannesen
dc.contributor.authorCooper, Alanen
dc.contributor.authorAlt, Kurt W.en
dc.contributor.authorBrown, Dorcasen
dc.contributor.authorAnthony, Daviden
dc.contributor.authorLalueza-Fox, Carlesen
dc.contributor.authorHaak, Wolfgangen
dc.contributor.authorPinhasi, Ronen
dc.contributor.authorReich, Daviden
dc.date.accessioned2025-05-24T14:23:52Z
dc.date.available2025-05-24T14:23:52Z
dc.date.issued2015-12-24en
dc.description.abstractAncient DNA makes it possible to observe natural selection directly by analysing samples from populations before, during and after adaptation events. Here we report a genome-wide scan for selection using ancient DNA, capitalizing on the largest ancient DNA data set yet assembled: 230 West Eurasians who lived between 6500 and 300 bc, including 163 with newly reported data. The new samples include, to our knowledge, the first genome-wide ancient DNA from Anatolian Neolithic farmers, whose genetic material we obtained by extracting from petrous bones, and who we show were members of the population that was the source of Europe's first farmers. We also report a transect of the steppe region in Samara between 5600 and 300 bc, which allows us to identify admixture into the steppe from at least two external sources. We detect selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height.en
dc.description.sponsorshipAcknowledgements We thank P. de Bakker, J. Burger, C. Economou, E. Fornander, Q. Fu, F. Hallgren, K. Kirsanow, A. Mittnik, I. Olalde, A. Powell, P. Skoglund, S. Tabrizi and A. Tandon for discussions, suggestions about SNPs to include, or contribution to sample preparation or data curation. We thank S. Pääbo, M. Meyer, Q. Fu and B. Nickel for collaboration in developing the 1240k capture reagent. We thank J. M. V. Encinas and M. E. Prada for allowing us to resample La Braña 1. I.M. was supported by the Human Frontier Science Program LT001095/2014-L. C.G. was supported by the Irish Research Council for Humanities and Social Sciences (IRCHSS). F.G. was supported by a grant of the Netherlands Organization for Scientific Research, no. 380-62-005. A.K., P.K. and O.M. were supported by RFBR no. 15-06-01916 and RFH no. 15-11-63008 and O.M. by a state grant of the Ministry of Education and Science of the Russia Federation no. 33.1195.2014/k. J.K. was supported by ERC starting grant APGREID and DFG grant KR 4015/1-1. K.W.A. was supported by DFG grant AL 287 / 14-1. C.L.-F. was supported by a BFU2015-64699-P grant from the Spanish government. W.H. and B.L. were supported by Australian Research Council DP130102158. R.P. was supported by ERC starting grant ADNABIOARC (263441), and an Irish Research Council ERC support grant. D.R. was supported by US National Science Foundation HOMINID grant BCS-1032255, US National Institutes of Health grant GM100233, and the Howard Hughes Medical Institute.en
dc.description.statusPeer-revieweden
dc.format.extent5en
dc.identifier.issn0028-0836en
dc.identifier.otherPubMed:26595274en
dc.identifier.otherORCID:/0000-0002-5550-9176/work/162945974en
dc.identifier.scopus84951286136en
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84951286136&partnerID=8YFLogxKen
dc.identifier.urihttps://hdl.handle.net/1885/733753233
dc.language.isoenen
dc.rightsPublisher Copyright: © 2015 Macmillan Publishers Limited. All rights reserved.en
dc.sourceNatureen
dc.titleGenome-wide patterns of selection in 230 ancient Eurasiansen
dc.typeJournal articleen
dspace.entity.typePublicationen
local.bibliographicCitation.lastpage503en
local.bibliographicCitation.startpage499en
local.contributor.affiliationMathieson, Iain; Harvard Universityen
local.contributor.affiliationLazaridis, Iosif; Harvard Universityen
local.contributor.affiliationRohland, Nadin; Harvard Universityen
local.contributor.affiliationMallick, Swapan; Harvard Universityen
local.contributor.affiliationPatterson, Nick; Eli and Edythe L. Broad Institute of MIT and Harvarden
local.contributor.affiliationRoodenberg, Songül Alpaslan; Santpoort-Noorden
local.contributor.affiliationHarney, Eadaoin; Harvard Universityen
local.contributor.affiliationStewardson, Kristin; Harvard Universityen
local.contributor.affiliationFernandes, Daniel; University College Dublinen
local.contributor.affiliationNovak, Mario; University College Dublinen
local.contributor.affiliationSirak, Kendra; University College Dublinen
local.contributor.affiliationGamba, Cristina; University College Dublinen
local.contributor.affiliationJones, Eppie R.; Trinity College Dublinen
local.contributor.affiliationLlamas, Bastien; Australian Centre for Ancient DNAen
local.contributor.affiliationDryomov, Stanislav; RAS - Institute of Molecular and Cellular Biology, Siberian Branchen
local.contributor.affiliationPickrell, Joseph; Harvard Universityen
local.contributor.affiliationArsuaga, Juan Luís; Instituto de Salud Carlos IIIen
local.contributor.affiliationDe Castro, José María Bermúdez; National Research Center On Human Evolutionen
local.contributor.affiliationCarbonell, Eudald; Universitat Rovira i Virgili (URV)en
local.contributor.affiliationGerritsen, Fokke; Netherlands Institute in Turkeyen
local.contributor.affiliationKhokhlov, Aleksandr; Samara State University of Social Sciences and Educationen
local.contributor.affiliationKuznetsov, Pavel; Samara State University of Social Sciences and Educationen
local.contributor.affiliationLozano, Marina; Universitat Rovira i Virgili (URV)en
local.contributor.affiliationMeller, Harald; State Museum of Prehistoryen
local.contributor.affiliationMochalov, Oleg; Samara State University of Social Sciences and Educationen
local.contributor.affiliationMoiseyev, Vyacheslav; Russian Academy of Sciencesen
local.contributor.affiliationGuerra, Manuel A.Rojo; University of Valladoliden
local.contributor.affiliationRoodenberg, Jacob; Leiden Universityen
local.contributor.affiliationVergès, Josep Maria; Universitat Rovira i Virgili (URV)en
local.contributor.affiliationKrause, Johannes; Max Planck Institute of Geoanthropologyen
local.contributor.affiliationCooper, Alan; Australian Centre for Ancient DNAen
local.contributor.affiliationAlt, Kurt W.; State Museum of Prehistoryen
local.contributor.affiliationBrown, Dorcas; Hartwick Collegeen
local.contributor.affiliationAnthony, David; Hartwick Collegeen
local.contributor.affiliationLalueza-Fox, Carles; Pompeu Fabra)en
local.contributor.affiliationHaak, Wolfgang; University of Adelaideen
local.contributor.affiliationPinhasi, Ron; University College Dublinen
local.contributor.affiliationReich, David; Harvard Universityen
local.identifier.citationvolume528en
local.identifier.doi10.1038/nature16152en
local.identifier.pureb7a7023e-2646-4127-b76f-bb42562abf23en
local.identifier.urlhttps://www.scopus.com/pages/publications/84951286136en
local.type.statusPublisheden

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