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Beyond the discovery void: New targets for antibacterial compounds

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Date

2016

Authors

Broughton, Claire E.
Van Den Berg, Hugo A.
Wemyss, Alan M.
Roper, David I.
Rodger, Alison

Journal Title

Journal ISSN

Volume Title

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Access Statement

Research Projects

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Abstract

Antibiotics save many lives, but their efficacy is under threat: overprescription, populationgrowth, and global travel all contribute to the rapid origination and spread of resistantstrains. Exacerbating this threat is the fact that no new major classes of antibioticshave been discovered in the last 30 years: this is the “discovery void.” We discuss thetraditional molecular targets of antibiotics as well as putative novel targets.

Description

Keywords

Antibiotics, Bacterial resistances to antibiotics, Cell division, Cellwall, Discovery void, MRSA

Citation

URI

http://www.scopus.com/inward/record.url?scp=84975065694&partnerID=8YFLogxK
 https://hdl.handle.net/1885/733765630

Collections

ANU Research Publications

Source

Science Progress

Type

Journal article

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Entity type

Publication

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DOI

10.3184/003685016X14616130512308

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