Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles
| dc.contributor.author | Shang, Minghao | en |
| dc.contributor.author | He, Junming | en |
| dc.contributor.author | Gardiner, Michael G. | en |
| dc.contributor.author | Nitsche, Christoph | en |
| dc.date.accessioned | 2025-06-12T01:33:55Z | |
| dc.date.available | 2025-06-12T01:33:55Z | |
| dc.date.issued | 2024 | en |
| dc.description.abstract | Macrocyclic peptides containing a thiazole heterocycle exhibit fascinating properties in natural products and future therapeutics. We report a biocompatible macrocyclisation approach facilitated by an N-terminal cysteine and C-terminal nitriles. The use of various chiral alpha-amino nitriles enables the incorporation of diverse hydrophobic side chains adjacent to the thiazole motif. | en |
| dc.description.sponsorship | CN thanks the Australian Research Council for funding support, including a Discovery Project (DP230100079) and Future Fellowship (FT220100010). We thank Dr Douglas Lawes (ANU) for assistance in recording NMR spectra. | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 4 | en |
| dc.identifier.issn | 1477-0520 | en |
| dc.identifier.other | WOS:001390652000001 | en |
| dc.identifier.other | PubMed:39775491 | en |
| dc.identifier.other | ORCID:/0000-0002-3704-2699/work/176533592 | en |
| dc.identifier.scopus | 85214585446 | en |
| dc.identifier.uri | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:001390652000001&DestLinkType=FullRecord&DestApp=WOS_CPL | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733759891 | |
| dc.language.iso | en | en |
| dc.source | Organic and Biomolecular Chemistry | en |
| dc.subject | Cyclic peptide | en |
| dc.subject | Hexapeptides | en |
| dc.title | Biocompatible synthesis of macrocyclic thiazole peptides from chiral α-amino nitriles | en |
| dc.type | Commentary | en |
| dspace.entity.type | Publication | en |
| local.contributor.affiliation | Shang, Minghao; The Australian National University | en |
| local.contributor.affiliation | He, Junming; The Australian National University | en |
| local.contributor.affiliation | Gardiner, Michael G.; The Australian National University | en |
| local.contributor.affiliation | Nitsche, Christoph; The Australian National University | en |
| local.identifier.doi | 10.1039/d4ob01989j | en |
| local.identifier.pure | b0625345-a6c1-4899-8d73-3954919a495d | en |
| local.identifier.url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:001390652000001&DestLinkType=FullRecord&DestApp=WOS_CPL | en |
| local.identifier.url | https://www.scopus.com/pages/publications/85214585446 | en |
| local.type.status | Published | en |
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