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Gene-Mediated Chemical Communication in Synthetic Protocell Communities

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Date

2017-11-01

Authors

Tang, T. Y.Dora
Cecchi, Dario
Fracasso, Giorgio
Accardi, Davide
Coutable-Pennarun, Angelique
Mansy, Sheref S.
Perriman, Adam W.
Anderson, J. L.Ross
Mann, Stephen

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Abstract

A gene-directed chemical communication pathway between synthetic protocell signaling transmitters (lipid vesicles) and receivers (proteinosomes) was designed, built and tested using a bottom-up modular approach comprising small molecule transcriptional control, cell-free gene expression, porin-directed efflux, substrate signaling, and enzyme cascade-mediated processing.

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Keywords

cell-free expression, communication, enzyme cascade, genetic switches, lipid vesicles, proteinosomes, α-hemolysin

Citation

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https://hdl.handle.net/1885/733807951

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ANU Research Publications

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ACS Synthetic Biology

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Journal article

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DOI

10.1021/acssynbio.7b00306

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