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The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

Bruestle, Anne; Heink, Sylvia; Huber, Magdalena; Rosenplaenter, C; Stadelmann, C; Yu, Philipp; Arpaia, E; Mak, TW; Kamradt, Thomas; Lohoff, Michael

Description

Interferon-regulatory factor 4 (IRF4) is essential for the development of T helper type 2 cells. Here we show that IRF4 is also critical for the generation of interleukin 17–producing T helper cells (TH-17 cells), which are associated with experimental autoimmune encephalomyelitis. IRF4-deficient (Irf4–/–) mice did not develop experimental autoimmune encephalomyelitis, and T helper cells from such mice failed to differentiate into TH-17 cells. Transfer of wild-type T helper cells into Irf4–/–...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/98987
Source: Nature Immunology
DOI: 10.1038/ni1500

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