Malaria parasite specific TH1-like cells simultaneously reduce parasitaemia and promote disease
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Hirunpetcharat, Chakrit; Finkelman, Fred; Clark, Ian A; Good, Michael
Description
CD4+ T cells have been implicated in immunity to the blood stages of malaria and cytokines associated with both monocyte and T cell activation have been implicated in disease. To determine whether specific T cells capable of inhibiting parasite growth can also mediate pathology we have transfused populations of Plasmodium berghei-specific T cells into normal and immunodeficient naive mice. We observed that they could inhibit parasite growth but were unable to save the animals which exhibited...[Show more]
dc.contributor.author | Hirunpetcharat, Chakrit | |
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dc.contributor.author | Finkelman, Fred | |
dc.contributor.author | Clark, Ian A | |
dc.contributor.author | Good, Michael | |
dc.date.accessioned | 2015-12-13T23:22:35Z | |
dc.identifier.issn | 0141-9838 | |
dc.identifier.uri | http://hdl.handle.net/1885/91524 | |
dc.description.abstract | CD4+ T cells have been implicated in immunity to the blood stages of malaria and cytokines associated with both monocyte and T cell activation have been implicated in disease. To determine whether specific T cells capable of inhibiting parasite growth can also mediate pathology we have transfused populations of Plasmodium berghei-specific T cells into normal and immunodeficient naive mice. We observed that they could inhibit parasite growth but were unable to save the animals which exhibited significantly greater anaemia and weight loss than control infected animals receiving either no T cells or T cells specific for ovalbumin. T cell-dependent tomour necrosis factor (TNF)α was a critical component in both parasite killing and disease promotion. Experiments with blocking antibodies demonstrated that all T-cell mediated antiparasitic immunity and all T-cell mediated weight loss was TNF-dependent. Blocking TNF-α in mice that received parasite-specific T cells prolonged the survival of the mice. Nitic oxide demonstrated no antiparasite effect, but was involved in the regulation of T-cell mediated weight loss. The data thus show that while parasite-specific CD4+ T cells can significantly limit parasite growth, such an effect need not be beneficial to the host, and that TNF-α and nitric oxide are critical effector molecules operating downstream of parasite-specific T cells in both immunity and disease. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.source | Parasite Immunology | |
dc.subject | Keywords: cd4 antigen; nitric oxide; ovalbumin; tumor necrosis factor alpha; anemia; animal cell; animal experiment; animal model; article; controlled study; disease course; female; helper cell; immune deficiency; malaria; mouse; nonhuman; parasitemia; plasmodium b Disease pathogenesis; Nitric oxide; Plasmodium berghei; TNF-a | |
dc.title | Malaria parasite specific TH1-like cells simultaneously reduce parasitaemia and promote disease | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 21 | |
dc.date.issued | 1999 | |
local.identifier.absfor | 110803 - Medical Parasitology | |
local.identifier.ariespublication | MigratedxPub22288 | |
local.type.status | Published Version | |
local.contributor.affiliation | Hirunpetcharat, Chakrit, Royal Brisbane Hospital | |
local.contributor.affiliation | Finkelman, Fred, University of Cincinnati | |
local.contributor.affiliation | Clark, Ian A, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Good, Michael, Royal Brisbane Hospital | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 319 | |
local.bibliographicCitation.lastpage | 329 | |
local.identifier.doi | 10.1046/j.1365-3024.1999.00234.x | |
dc.date.updated | 2015-12-12T09:11:40Z | |
local.identifier.scopusID | 2-s2.0-0033036997 | |
Collections | ANU Research Publications |
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