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Glucocorticoid-induced hypertension: from mouse to man

Whitworth, Judith; Schyvens, Chris; Zhang, Yafei; Mangos, George; Kelly, John


1. Adrenocorticotrophic hormone (ACTH) raises blood pressure in humans, sheep, rat and mouse. In rat and humans, but not sheep, the hypertension can be explained by glucocorticoid excess. 2. In both rat and humans, the hypertension is associated with a rise in cardiac output and renal vascular resistance. 3. In both rat and humans, the nitric oxide system is implicated in glucocorticoid hypertension. 4. In both rat and humans, hypertension due to naturally occurring glucocorticoids is not...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1046/j.1440-1681.2001.03584.x


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