Glucocorticoid-induced hypertension: from mouse to man
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Whitworth, Judith; Schyvens, Chris; Zhang, Yafei; Mangos, George; Kelly, John
Description
1. Adrenocorticotrophic hormone (ACTH) raises blood pressure in humans, sheep, rat and mouse. In rat and humans, but not sheep, the hypertension can be explained by glucocorticoid excess. 2. In both rat and humans, the hypertension is associated with a rise in cardiac output and renal vascular resistance. 3. In both rat and humans, the nitric oxide system is implicated in glucocorticoid hypertension. 4. In both rat and humans, hypertension due to naturally occurring glucocorticoids is not...[Show more]
Collections | ANU Research Publications |
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Date published: | 2001 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/90723 |
Source: | Clinical and Experimental Pharmacology and Physiology |
DOI: | 10.1046/j.1440-1681.2001.03584.x |
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