Lipopolysaccharide Reverses Adrenocorticotrophic Hormone-Induced Hypertension in the Rat
-
Altmetric Citations
Zhang, Yi; Schyvens, Chris; McKenzie, Katja; Morris, Brian; Whitworth, Judith
Description
Lipopolysaccharide (LPS) was used to stimulate nitric oxide (NO) release and investigate the effect of endogenous NO on adrenocorticotrophic hormone (ACTH)-induced hypertension in rats. After preliminary studies to determine the appropriate dose of LPS, 40 male Sprague-Dawley rats were treated with ACTH (200 μg/kg/day, s.c.) or saline (sham) for 8 days and then given a single dose of LPS (10 mg/kg, i.p.) or saline. ACTH treatment was continued for a further 5 days. Systolic blood pressure (SBP)...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2003 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/87803 |
Source: | Hypertension Research |
DOI: | 10.1291/hypres.26.427 |
Download
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator