Alsharifi, Mohammed; Lobigs, Mario; Simon, Markus M; Kersten, A; Muller, Klaus; Koskinen, Aulikki; Lee, Eva; Mullbacher, Arno
Natural killer (NK) and cytotoxic T (Tc) cells are prime effector populations in the antiviral response of the host. Tc cells are essential for recovery from many viral diseases but may also be responsible for immunopathology. The role of NK cells in recovery from viral infections is less well established. We have studied acute virulent Semliki Forest virus (vSFV) infection of the central nervous system in C57BL/6J mice, which was mainly controlled by NK cells without marked Tc cell...[Show more]
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