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NK cell-mediated immunopathology during an acute viral infection of the CNS

Alsharifi, Mohammed; Lobigs, Mario; Simon, Markus M; Kersten, A; Muller, Klaus; Koskinen, Aulikki; Lee, Eva; Mullbacher, Arno


Natural killer (NK) and cytotoxic T (Tc) cells are prime effector populations in the antiviral response of the host. Tc cells are essential for recovery from many viral diseases but may also be responsible for immunopathology. The role of NK cells in recovery from viral infections is less well established. We have studied acute virulent Semliki Forest virus (vSFV) infection of the central nervous system in C57BL/6J mice, which was mainly controlled by NK cells without marked Tc cell...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: European Journal of Immunology
DOI: 10.1002/eji.200535342


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