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A novel β-oxa polyunsaturated fatty acid downregulates the activation of the IκB kinase/nuclear factor κB pathway, inhibits expression of endothelial cell adhesion molecules, and depresses inflammation

Ferrante, Antonio; Robinson, Brenton S; Singh, Harmeet; Jersmann, Herbertus; Ferrante, Judith V; Huang, Zhi H; Trout, Neil A; Pitt, Michael J; Rathjen, Deborah A; Easton, Christopher; Poulos, Alf; Prager, Rolf H; Lee, Frank S; Hii, Charles

Description

Several novel polyunsaturated fatty acids (PUFAs) that contain either an oxygen or sulfur atom in the β-position were found to exhibit more selective antiinflammatory properties than their natural PUFA counterparts. One of these, β-oxa-23:4n-6, unlike n

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/84977
Source: Circulation Research
DOI: 10.1161/01.RES.0000231292.66084.cd

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