Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use
-
Altmetric Citations
Thomson, Scott; Jaramillo, Angel B; Shoobridge, Maryanne; Dunstan, Kerrie J; Everett, Beth; Kent, Stephen J; Gao, Ke; Medveczky, C; Ffrench, Rosemary A; Ramshaw, Ian; Ranasinghe, Charani
Description
Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode more antigens safely and is very flexible compared to traditional isolate-based strategies. The SAVINE...[Show more]
dc.contributor.author | Thomson, Scott | |
---|---|---|
dc.contributor.author | Jaramillo, Angel B | |
dc.contributor.author | Shoobridge, Maryanne | |
dc.contributor.author | Dunstan, Kerrie J | |
dc.contributor.author | Everett, Beth | |
dc.contributor.author | Kent, Stephen J | |
dc.contributor.author | Gao, Ke | |
dc.contributor.author | Medveczky, C | |
dc.contributor.author | Ffrench, Rosemary A | |
dc.contributor.author | Ramshaw, Ian | |
dc.contributor.author | Ranasinghe, Charani | |
dc.date.accessioned | 2015-12-13T23:00:13Z | |
dc.identifier.issn | 0264-410X | |
dc.identifier.uri | http://hdl.handle.net/1885/84024 | |
dc.description.abstract | Induction of high levels of broadly reactive cytotoxic T lymphocytes (CTL) remains a promising approach for an effective HIV-1 vaccine. We have developed a novel genetic-based vaccine strategy that encodes consensus overlapping peptide sets from all HIV-1 proteins scrambled together. This synthetic scrambled antigen vaccine (SAVINE) strategy has significant advantages, e.g. capacity to encode more antigens safely and is very flexible compared to traditional isolate-based strategies. The SAVINE vaccine strategy is clearly immunogenic, being able to restimulate a range of human HIV-1 specific responses in vitro and induce HIV-1 specific immunity in vivo in mice. Interestingly, different in vivo delivery strategies affected the resulting immunity and immunodominance pattern in mice. This platform strategy could be used for other infections and cancers where T cell responses are important for protection. | |
dc.publisher | Elsevier | |
dc.source | Vaccine | |
dc.subject | Keywords: Human immunodeficiency virus antigen; Human immunodeficiency virus vaccine; amino acid sequence; animal cell; animal experiment; article; cellular immunity; consensus sequence; controlled study; cytotoxic T lymphocyte; drug design; drug synthesis; female; Synthetic HIV vaccine | |
dc.title | Development of a synthetic consensus sequence scrambled antigen HIV-1 vaccine designed for global use | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 23 | |
dc.date.issued | 2005 | |
local.identifier.absfor | 110799 - Immunology not elsewhere classified | |
local.identifier.ariespublication | MigratedxPub12290 | |
local.type.status | Published Version | |
local.contributor.affiliation | Thomson, Scott, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Jaramillo, Angel B, University of New South Wales | |
local.contributor.affiliation | Shoobridge, Maryanne, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Dunstan, Kerrie J, University of New South Wales | |
local.contributor.affiliation | Everett, Beth, University of New South Wales | |
local.contributor.affiliation | Ranasinghe, Charani, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Kent, Stephen J, University of Melbourne | |
local.contributor.affiliation | Gao, Ke, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Medveczky, C, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Ffrench, Rosemary A, University of New South Wales | |
local.contributor.affiliation | Ramshaw, Ian, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 4647 | |
local.bibliographicCitation.lastpage | 4657 | |
local.identifier.doi | 10.1016/j.vaccine.2005.04.045 | |
dc.date.updated | 2015-12-12T07:32:41Z | |
local.identifier.scopusID | 2-s2.0-23644454804 | |
Collections | ANU Research Publications |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Thomson_Development_of_a_synthetic_2005.pdf | 536.52 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator