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Mitochondrial monoamine oxidase-A-mediated hydrogen peroxide generation enhances 5-hydroxytryptamine-induced contraction of rat basilar artery

Li, Rachel; Poon, Christina Chui Wa; Seto, Sai Wang; Au, Alice Lai Shan; Zhang, Qian; Lee, Wayne Yuk Wai; Leung, George P. H.; Kong, Siu Kai; Yeung, John Hok Keung; Ngai, Sai Ming; Ho, Ho Pui


BACKGROUND AND PURPOSE We evaluated the role(s) of monoamine oxidase (MAO)-mediated H2O2 generation on 5-hydroxytryptamine (5-HT)-induced tension development of isolated basilar artery of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. EXPERIMENTAL APPROACH Basilar artery (endothelium-denuded) was isolated for tension measurement and Western blots. Enzymically dissociated single myocytes from basilar arteries were used for patch-clamp electrophysiological and...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: British Journal of Pharmacology
DOI: 10.1111/j.1476-5381.2010.00941.x


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