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Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations

Cheng, Riyan; Lim, Jackie E; Samocha, Kaitlin E.; Sokoloff, Greta; Abney, Mark; Skol, Andrew D; Palmer, Abraham A


Model organisms offer many advantages for the genetic analysis of complex traits. However, identification of specific genes is often hampered by a lack of recombination between the genomes of inbred progenitors. Recently, genome-wide association studies (GWAS) in humans have offered gene-level mapping resolution that is possible because of the large number of accumulated recombinations among unrelated human subjects. To obtain analogous improvements in mapping resolution in mice, we used a 34th...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Genetics (Print) ceased Dec 2009 - don't use
DOI: 10.1534/genetics.110.116863


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