Genome-wide association studies and the problem of relatedness among advanced intercross lines and other highly recombinant populations
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Cheng, Riyan; Lim, Jackie E; Samocha, Kaitlin E.; Sokoloff, Greta; Abney, Mark; Skol, Andrew D; Palmer, Abraham A
Description
Model organisms offer many advantages for the genetic analysis of complex traits. However, identification of specific genes is often hampered by a lack of recombination between the genomes of inbred progenitors. Recently, genome-wide association studies (GWAS) in humans have offered gene-level mapping resolution that is possible because of the large number of accumulated recombinations among unrelated human subjects. To obtain analogous improvements in mapping resolution in mice, we used a 34th...[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/79469 |
Source: | Genetics (Print) ceased Dec 2009 - don't use |
DOI: | 10.1534/genetics.110.116863 |
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