Cheng, Riyan; Lim, Jackie E; Samocha, Kaitlin E.; Sokoloff, Greta; Abney, Mark; Skol, Andrew D; Palmer, Abraham A
Model organisms offer many advantages for the genetic analysis of complex traits. However, identification of specific genes is often hampered by a lack of recombination between the genomes of inbred progenitors. Recently, genome-wide association studies (GWAS) in humans have offered gene-level mapping resolution that is possible because of the large number of accumulated recombinations among unrelated human subjects. To obtain analogous improvements in mapping resolution in mice, we used a 34th...[Show more]
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