β-Nitro-α-amino Acids as Latent α,β-Dehydro-α-amino Acid Residues in Solid-Phase Peptide Synthesis

Abstract

β-Nitro-α-amino acids, that are readily accessible through either the reaction of bromoglycine derivatives with alkyl nitronates or the three-component coupling of amines, nitroalkanes and glyoxalate in aqueous base, are easily converted to the correspo