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Synthesis and structure-activity relationship studies of the calothrixins and other redox-active compounds

Bernardo, Paul Huntington

Description

Calothrixin A and B are novel pentacycIic qui nones that have been isolated from the Calothrix cyanobacteria. The calothrixins exhibit anti proliferative activity against chloroquine resistant strains of Plasmodium falciparum, the deadliest causative agent of malaria. Furthermore, these compounds have potent and selective activity against a range of human cancer cell lines. These biological properties have led to the identification of the calothrixins as lead compounds for drug...[Show more]

CollectionsOpen Access Theses
Date published: 2011-04-07
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/7171

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