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Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine

Laver, Derek Rowland; Lenz, Gerlende; Lamb, Graham


1. Nucleotide activation of skeletal muscle ryanodine receptors (RyRs) was studied in planar lipid bilayers in order to understand RyR regulation in vivo under normal and fatigued conditions. With 'resting' calcium (100 nM cytoplasmic and 1 mM luminal), RyRs had an open probability (Po) of ∼0.01 in the absence of nucleotides and magnesium. ATP reversibly activated RyRs with Po at saturation (Pmax) ∼0.33 and Ka (concentration for half-maximal activation) ∼0.36 mM and with a Hill coefficient (nH)...[Show more]

CollectionsANU Research Publications
Date published: 2001
Type: Journal article
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2001.012775


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