Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level
The adipocyte-derived cytokine leptin acts as a metabolic switch, connecting the body's metabolism to high-energy consuming processes such as reproduction and immune responses. We here provide genetic and biochemical evidence that the metabolic and immune functions of leptin can be uncoupled at the receptor level. First, homozygous mutant fatt/fatt mice carry a spontaneous splice mutation causing deletion of the leptin receptor (LR) immunoglobulin-like domain (IGD) in all LR isoforms. These...[Show more]
|Collections||ANU Research Publications|
|Source:||Cellular and Molecular Life Sciences|
|01_Zabeau_Leptin's_metabolic_and_immune_2014.pdf||1.3 MB||Adobe PDF||Request a copy|
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