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Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Zabeau, Lennart; Jensen, Cathy J; Seeuws, Sylvie; Venken, Koen; Verhee, Annick; Catteeuw, Dominiek; van Loo, Geert; Chen, Hui; Foote, Simon; Morris, Margaret J; Van der Heyden, Jose


The adipocyte-derived cytokine leptin acts as a metabolic switch, connecting the body's metabolism to high-energy consuming processes such as reproduction and immune responses. We here provide genetic and biochemical evidence that the metabolic and immune functions of leptin can be uncoupled at the receptor level. First, homozygous mutant fatt/fatt mice carry a spontaneous splice mutation causing deletion of the leptin receptor (LR) immunoglobulin-like domain (IGD) in all LR isoforms. These...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Cellular and Molecular Life Sciences
DOI: 10.1007/s00018-014-1697-x


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