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Regulation of Focal Adhesions by Flightless I Involves Inhibition of Paxillin Phosphorylation via a Rac1-Dependent Pathway

Kopecki, Zlatko; O'Neill, Geraldine M.; Arkell, Ruth; Cowin, Allison J


Flightless I (Flii) is an actin-remodeling protein that influences diverse processes including cell migration and gene transcription and links signal transduction with cytoskeletal regulation. Here, we show that Flii modulation of focal adhesions and filamentous actin stress fibers is Rac1-dependent. Using primary skin fibroblasts from Flii overexpressing (FliiTg/Tg), wild-type, and Flii deficient (Flii+/-) mice, we show that elevated expression of Flii increases stress fiber formation by...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: The Journal of Investigative Dermatology
DOI: 10.1038/jid.2011.69


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