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Functional analysis of the short isoform of orf virus protein OV20.0

Tseng, Yeu-Yang; Lin, Fong-Yuan; Cheng, Sun-Fang; Tscharke, David; Chulakasian, Songkhla; Chou, Chia-Chi; Liu, Ya-Fen; Chang, Wei-Shan; Wong, Min-Liang; Hsu, Wei-Li


Orf virus (ORFV) OV20.0L is an ortholog of vaccinia virus (VACV) gene E3L. The function of VACV E3 protein as a virulence factor is well studied, but OV20.0 has received less attention. Here we show that like VACV E3L, OV20.0L encodes two proteins, a full-length protein and a shorter form (sh20). The shorter sh20 is an N-terminally truncated OV20.0 isoform generated when a downstream AUG codon is used for initiating translation. These isoforms differed in cellular localization, with full-length...[Show more]

CollectionsANU Research Publications
Date published: 2015
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.03714-14
Access Rights: Open Access


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