Functional analysis of the short isoform of orf virus protein OV20.0
Orf virus (ORFV) OV20.0L is an ortholog of vaccinia virus (VACV) gene E3L. The function of VACV E3 protein as a virulence factor is well studied, but OV20.0 has received less attention. Here we show that like VACV E3L, OV20.0L encodes two proteins, a full-length protein and a shorter form (sh20). The shorter sh20 is an N-terminally truncated OV20.0 isoform generated when a downstream AUG codon is used for initiating translation. These isoforms differed in cellular localization, with full-length...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Virology|
|Access Rights:||Open Access|
|01_Tseng_Functional_analysis_of_the_2015.pdf||2.68 MB||Adobe PDF|
|02_Tseng_Functional_analysis_of_the_2015.pdf||2.68 MB||Adobe PDF|
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