Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo
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Fossat, Nicolas; Jones, Vanessa; Khoo, Poh-Lynn; Bogani, Debora; Hardy, Andrea; Steiner, Kirsten; Mukhopadhyay, Mahua; Westphal, Heiner; Nolan, Patrick; Arkell, Ruth; Tam, Patrick
Description
In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses in the precursors of the craniofacial structures and leads to a complete truncation of the head at early organogenesis. Here, we show that ENU-induced mutations of genes coding for two WNT canonical pathway factors, the co-receptor LRP6 and the transcriptional co-activator β-catenin, also elicit an ectopic signalling response and result in loss of the rostral tissues of the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/66666 |
Source: | Development |
DOI: | 10.1242/dev.052803 |
Access Rights: | Open Access |
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01_Fossat_Stringent_requirement_of_a_2011.pdf | 2.87 MB | Adobe PDF |
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