Skip navigation
Skip navigation

Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo

Fossat, Nicolas; Jones, Vanessa; Khoo, Poh-Lynn; Bogani, Debora; Hardy, Andrea; Steiner, Kirsten; Mukhopadhyay, Mahua; Westphal, Heiner; Nolan, Patrick; Arkell, Ruth; Tam, Patrick


In mouse embryos, loss of Dickkopf-1 (DKK1) activity is associated with an ectopic activation of WNT signalling responses in the precursors of the craniofacial structures and leads to a complete truncation of the head at early organogenesis. Here, we show that ENU-induced mutations of genes coding for two WNT canonical pathway factors, the co-receptor LRP6 and the transcriptional co-activator β-catenin, also elicit an ectopic signalling response and result in loss of the rostral tissues of the...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Development
DOI: 10.1242/dev.052803
Access Rights: Open Access


File Description SizeFormat Image
01_Fossat_Stringent_requirement_of_a_2011.pdf2.87 MBAdobe PDF

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator