Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo
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Lynn, Helena; Horsington, Jacquelyn; Ter, Lee (Felix); Han, Shuyi; Chew, Yee Lian; Diefenbach, Russell J; Way, Michael; Chaudhri, Geeta; Karupiah, Gunasegaran; Newsome, Timothy
Description
Egress of wrapped virus (WV) to the cell periphery following vaccinia virus (VACV) replication is dependent on interactions with the microtubule motor complex kinesin-1 and is mediated by the viral envelope protein A36. Here we report that ectromelia virus (ECTV), a related orthopoxvirus and the causative agent of mousepox, encodes an A36 homologue (ECTV-Mos-142) that is highly conserved despite a large truncation at the C terminus. Deleting the ECTV A36R gene leads to a reduction in the number...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/65348 |
Source: | Journal of Virology |
DOI: | 10.1128/JVI.06636-11 |
Access Rights: | Open Access |
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01_Lynn_Loss_of_cytoskeletal_transport_2012.pdf | 4.39 MB | Adobe PDF |
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