Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo
Egress of wrapped virus (WV) to the cell periphery following vaccinia virus (VACV) replication is dependent on interactions with the microtubule motor complex kinesin-1 and is mediated by the viral envelope protein A36. Here we report that ectromelia virus (ECTV), a related orthopoxvirus and the causative agent of mousepox, encodes an A36 homologue (ECTV-Mos-142) that is highly conserved despite a large truncation at the C terminus. Deleting the ECTV A36R gene leads to a reduction in the number...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Virology|
|Access Rights:||Open Access|
|01_Lynn_Loss_of_cytoskeletal_transport_2012.pdf||4.39 MB||Adobe PDF|
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