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Loss of cytoskeletal transport during egress critically attenuates ectromelia virus infection in vivo

Lynn, Helena; Horsington, Jacquelyn; Ter, Lee (Felix); Han, Shuyi; Chew, Yee Lian; Diefenbach, Russell J; Way, Michael; Chaudhri, Geeta; Karupiah, Gunasegaran; Newsome, Timothy


Egress of wrapped virus (WV) to the cell periphery following vaccinia virus (VACV) replication is dependent on interactions with the microtubule motor complex kinesin-1 and is mediated by the viral envelope protein A36. Here we report that ectromelia virus (ECTV), a related orthopoxvirus and the causative agent of mousepox, encodes an A36 homologue (ECTV-Mos-142) that is highly conserved despite a large truncation at the C terminus. Deleting the ECTV A36R gene leads to a reduction in the number...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Journal of Virology
DOI: 10.1128/JVI.06636-11
Access Rights: Open Access


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