Predicting channel function from channel structure using Brownian dynamics simulations
-
Altmetric Citations
Chung, Shin-Ho; Kuyucak, Serdar
Description
1. The transport process of ions across the potassium channel is studied using computer simulations. The shape of the model channel corresponds closely to that deduced from crystallography. 2. We first give an intuitive account of how the motion of ions experiencing an applied electric force and interacting with a dielectric boundary and charge residues on the channel wall can be simulated accurately by using a powerful supercomputer. 3. We then show how some of the salient features of ion...[Show more]
dc.contributor.author | Chung, Shin-Ho | |
---|---|---|
dc.contributor.author | Kuyucak, Serdar | |
dc.date.accessioned | 2015-12-10T23:13:17Z | |
dc.identifier.issn | 0305-1870 | |
dc.identifier.uri | http://hdl.handle.net/1885/64354 | |
dc.description.abstract | 1. The transport process of ions across the potassium channel is studied using computer simulations. The shape of the model channel corresponds closely to that deduced from crystallography. 2. We first give an intuitive account of how the motion of ions experiencing an applied electric force and interacting with a dielectric boundary and charge residues on the channel wall can be simulated accurately by using a powerful supercomputer. 3. We then show how some of the salient features of ion channels can he deduced by following the positions of ions at each discrete step over many millions of time steps. | |
dc.publisher | Blackwell Science Asia | |
dc.source | Clinical and Experimental Pharmacology and Physiology | |
dc.subject | Keywords: potassium channel; potassium ion; computer simulation; conference paper; crystal structure; ion conductance; membrane permeability; molecular dynamics; molecular model; potassium transport; prediction; Ion Transport; Models, Biological; Nonlinear Dynamics Brownian dynamics; Computer simulations; Ion channel; KcsA channel; Permeation theory; Potassium channel | |
dc.title | Predicting channel function from channel structure using Brownian dynamics simulations | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.description.refereed | Yes | |
local.identifier.citationvolume | 28 | |
dc.date.issued | 2001 | |
local.identifier.absfor | 020204 - Plasma Physics; Fusion Plasmas; Electrical Discharges | |
local.identifier.ariespublication | MigratedxPub922 | |
local.type.status | Published Version | |
local.contributor.affiliation | Chung, Shin-Ho, College of Physical and Mathematical Sciences, ANU | |
local.contributor.affiliation | Kuyucak, Serdar, College of Physical and Mathematical Sciences, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 89 | |
local.bibliographicCitation.lastpage | 94 | |
local.identifier.doi | 10.1046/j.1440-1681.2001.03408.x | |
dc.date.updated | 2015-12-10T09:38:15Z | |
local.identifier.scopusID | 2-s2.0-0035175174 | |
Collections | ANU Research Publications |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
01_Chung_Predicting_channel_function_2001.pdf | 312.52 kB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator