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Mouse Strains for the Ubiquitous or Conditional Overexpression of the Flii Gene

Thomsen, Nicole; Chappell, Anna; Ali, Radiya; Jones, Tamsin; Adams, Damian H; Matthaei, Klaus; Campbell, Hugh; Cowin, Allison J; Arkell, Ruth

Description

The gelsolin related actin binding protein, Flii, is able to regulate wound healing; mice with decreased Flii expression show improved wound healing whereas mice with elevated Flii expression exhibit impaired wound healing. In both mice and humans Flii expression increases with age and amelioration of FLII activity represents a possible therapeutic strategy for improved wound healing in humans. Despite analysis of Flii function in a variety of organisms we know little of the molecular...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/63083
Source: Genesis
DOI: 10.1002/dvg.20735

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