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The identification of new metallo-β-lactamase inhibitor leads from fragment-based screening

Vella, Peter; Hussein, Waleed M; Leung, Eleanor W W; Clayton, Daniel; Ollis, David; Mitic, Natasa; Schenk, Gerhard; McGeary, Ross Peter

Description

The emergence of metallo-β-lactamases (MBLs) capable of hydrolysing a broad spectrum of β-lactam antibiotics is particularly concerning for the future treatment of bacterial infections. This work describes the discovery of lead compounds for the develop

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
URI: http://hdl.handle.net/1885/58869
Source: Bioorganic and Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2011.04.027

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