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The region homologos to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals

Hore, Tim; Koina, Edda; Wakefield, Matthew; Graves, Jennifer

Description

Marsupial, as well as eutherian, mammals are subject to X chromosome inactivation in the somatic cells of females, although the phenotype and the molecular mechanism differ in important respects. Monotreme mammals appear to subscribe at least to a form of dosage compensation of X-borne genes. An important question is whether inactivation in these non-eutherian mammals involves co-ordination by a control locus homologous to the XIST gene and neighbouring genes, which play a key regulatory role...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/56956
Source: Chromosome Research
DOI: 10.1007/s10577-007-1119-0

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