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miRNA effects on mRNA closed-loop formation during translation initiation

Beilharz, TH; Humphreys, David T; Preiss, Thomas


A flurry of recent studies, carried out primarily in transfected cells or in vitro translation systems, have attempted to reveal the molecular means by which animal microRNAs (miRNAs) attenuate mRNA translation. Despite these intense efforts it has not yet been possible to derive a consensus model for such a mechanism. Here we summarise our own experimental contributions to this topic, which led us to propose that miRNAs control early translation initiation by affecting eukaryotic initiation...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Book chapter
DOI: 10.1007/978-3-642-03103-8


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