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Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms-the Beyond Ageing Project: a randomized controlled trial

Walker, Janine; Batterham, Philip; Mackinnon, Andrew; Jorm, Anthony F; Hickie, Ian B; Fenech, Michael; Kljakovic, Marjan; Crisp, Dimity; Christensen, Helen


Background: Evidence remains unclear as to whether folic acid (FA) and vitamin B-12 supplementation is effective in reducing depressive symptoms. Objectives: The objective was to determine whether oral FA + vitamin B-12 supplementation prevented cognitive decline in a cohort of community-dwelling older adults with elevated psychological distress. Design: A randomized controlled trial (RCT) with a completely crossed 2 x 2 x 2 factorial design comprising daily oral 400 μg FA + 100 μg vitamin B-12...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: American Journal of Clinical Nutrition
DOI: 10.3945/ajcn.110.007799


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