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Formal total synthesis of triptolide

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Miller, Natalie; Willis, Anthony; Sherburn, Michael

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A new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels-Alder reactions and a new deoxygenative aromatisation process.

dc.contributor.authorMiller, Natalie
dc.contributor.authorWillis, Anthony
dc.contributor.authorSherburn, Michael
dc.date.accessioned2015-12-10T22:14:08Z
dc.identifier.issn1359-7345
dc.identifier.urihttp://hdl.handle.net/1885/50128
dc.description.abstractA new approach to the medicinally-important natural product triptolide is significantly shorter than previous syntheses, highly convergent and avoids the use of protecting groups; key features include two Diels-Alder reactions and a new deoxygenative aromatisation process.
dc.publisherRoyal Society of Chemistry
dc.sourceChemical Communications
dc.subjectKeywords: natural product; triptolide; aromatization; article; deoxygenation; Diels Alder reaction; drug synthesis; Diterpenes; Epoxy Compounds; Phenanthrenes; Stereoisomerism
dc.titleFormal total synthesis of triptolide
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume2008/10
dc.date.issued2008
local.identifier.absfor030503 - Organic Chemical Synthesis
local.identifier.ariespublicationu4005981xPUB198
local.type.statusPublished Version
local.contributor.affiliationMiller, Natalie, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationWillis, Anthony, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationSherburn, Michael, College of Physical and Mathematical Sciences, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage1226
local.bibliographicCitation.lastpage1228
local.identifier.doi10.1039/b718754h
dc.date.updated2015-12-09T08:04:19Z
local.identifier.scopusID2-s2.0-40349084294
local.identifier.thomsonID000254579500021
CollectionsANU Research Publications

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