IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity
Forbes, Elizabeth E; Groschwitz, Katherine; Abonia, J Pablo; Brandt, Eric; Cohen, Elizabeth; Blanchard, Carine; Ahrens, Richard; Seidu, Luqman; Mckenzie, Andrew N; Strait, Richard; Finkelman, Fred; Foster, Paul S; Matthaei, Klaus; Rothenberg, Marc E; Hogan, Simon P
Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype...[Show more]
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|Source:||Journal of Experimental Medicine|
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