Skip navigation
Skip navigation

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

Forbes, Elizabeth E; Groschwitz, Katherine; Abonia, J Pablo; Brandt, Eric; Cohen, Elizabeth; Blanchard, Carine; Ahrens, Richard; Seidu, Luqman; Mckenzie, Andrew N; Strait, Richard; Finkelman, Fred; Foster, Paul S; Matthaei, Klaus; Rothenberg, Marc E; Hogan, Simon P


Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20071046


File Description SizeFormat Image
01_Forbes_IL-9-_and_mast_cell-mediated_2008.pdf2.56 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator