Correlates of protective immunity in poxvirus infection: where does antibody stand?
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Panchanathan, Vijay; Chaudhri, Geeta; Karupiah, Gunasegaran
Description
Even though smallpox has been eradicated, the threat of accidental or intentional release has highlighted the fact there is little consensus about correlates of protective immunity or immunity against re-infection with the causative poxvirus, variola virus (VARV). As the existing vaccine for smallpox has unacceptable rates of side effects and complications, new vaccines are urgently needed. Surrogate animal models of VARV infection in humans, including vaccinia virus (VACV) and ectromelia virus...[Show more]
dc.contributor.author | Panchanathan, Vijay | |
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dc.contributor.author | Chaudhri, Geeta | |
dc.contributor.author | Karupiah, Gunasegaran | |
dc.date.accessioned | 2015-12-08T22:18:32Z | |
dc.identifier.issn | 0818-9641 | |
dc.identifier.uri | http://hdl.handle.net/1885/31391 | |
dc.description.abstract | Even though smallpox has been eradicated, the threat of accidental or intentional release has highlighted the fact there is little consensus about correlates of protective immunity or immunity against re-infection with the causative poxvirus, variola virus (VARV). As the existing vaccine for smallpox has unacceptable rates of side effects and complications, new vaccines are urgently needed. Surrogate animal models of VARV infection in humans, including vaccinia virus (VACV) and ectromelia virus (ECTV) infection in mice, monkeypox virus (MPXV) infection in macaques have been used as tools to dissect the immune response to poxviruses. Mousepox, caused by ECTV, a natural mouse pathogen, is arguably the best surrogate small-animal model, as it shares many aspects of virus biology, pathology and clinical features with smallpox in humans. The requirements for recovery from a primary ECTV infection have been well characterized and include type I and II interferons, natural killer cells, CD4T cells, CD8T cell effector function and antibody. From a vaccine standpoint, it is imperative that the requirements for recovery from secondary infection are also identified. We have investigated host immune parameters in response to a secondary ECTV infection, and have identified that interferon and CD8T cell effector functions are not essential; however, T- and B-cell interaction and antibody are absolutely critical for recovery from a secondary challenge. The central role of antibody has been also been identified in the secondary response to other poxviruses. These findings have important clinical implications and would greatly assist the design of therapeutic interventions and new vaccines for smallpox. | |
dc.publisher | Blackwell Publishing Ltd | |
dc.source | Immunology and Cell Biology | |
dc.subject | Keywords: interferon; virus antibody; virus vaccine; antibody response; B lymphocyte; CD4+ T lymphocyte; CD8+ T lymphocyte; cell interaction; clinical feature; correlation analysis; cytokine production; Ectromelia virus; effector cell; genetic resistance; human; im Antibody; Ectromelia virus; Immunity; Poxvirus; Secondary infection; Smallpox | |
dc.title | Correlates of protective immunity in poxvirus infection: where does antibody stand? | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 86 | |
dc.date.issued | 2008 | |
local.identifier.absfor | 110799 - Immunology not elsewhere classified | |
local.identifier.ariespublication | u6800332xPUB82 | |
local.type.status | Published Version | |
local.contributor.affiliation | Panchanathan, Vijay, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Chaudhri, Geeta, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Karupiah, Gunasegaran, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 80 | |
local.bibliographicCitation.lastpage | 86 | |
local.identifier.doi | 10.1038/sj.icb.7100118 | |
dc.date.updated | 2015-12-08T08:17:22Z | |
local.identifier.scopusID | 2-s2.0-37849009631 | |
local.identifier.thomsonID | 000252113700015 | |
Collections | ANU Research Publications |
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