Primary bone retention in a young adult male with limb disuse: a bioarchaeological case study
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Walker, Meg; Oxenham, Marc; Nguyen, Mai Huong T.; Trinh, Hiep Hoang; Minh, Tran Thi; Nguyen, Lan Cuong; Matsumura, Hirofumi; Miszkiewicz, Justyna
Description
Bone mineral and mass are low in limb bones that experience prolonged lack of, or minimal, mechanical stimulation. Cases of ancient human limb paralysis offering an opportunity to examine histological markers of cortical bone modelling and remodelling are rare. To improve our understanding of the spectrum of bone tissue response to its muscular disuse environment in archaeological contexts, we tested whether bone histology in an individual afflicted with long-term loss of muscle function showed...[Show more]
dc.contributor.author | Walker, Meg | |
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dc.contributor.author | Oxenham, Marc | |
dc.contributor.author | Nguyen, Mai Huong T. | |
dc.contributor.author | Trinh, Hiep Hoang | |
dc.contributor.author | Minh, Tran Thi | |
dc.contributor.author | Nguyen, Lan Cuong | |
dc.contributor.author | Matsumura, Hirofumi | |
dc.contributor.author | Miszkiewicz, Justyna | |
dc.date.accessioned | 2024-02-07T03:21:18Z | |
dc.date.available | 2024-02-07T03:21:18Z | |
dc.identifier.citation | Meg M. Walker, Marc F. Oxenham, Thi Mai Huong Nguyen, Hiep Hoang Trinh, Tran Thi Minh, Lan Cuong Nguyen, Hirofumi Matsumura & Justyna J. Miszkiewicz (2023) Primary bone retention in a young adult male with limb disuse: a bioarchaeological case study, Historical Biology, 35:2, 235-241, DOI: 10.1080/08912963.2022.2032027 | |
dc.identifier.issn | 0891-2963 | |
dc.identifier.uri | http://hdl.handle.net/1885/313316 | |
dc.description.abstract | Bone mineral and mass are low in limb bones that experience prolonged lack of, or minimal, mechanical stimulation. Cases of ancient human limb paralysis offering an opportunity to examine histological markers of cortical bone modelling and remodelling are rare. To improve our understanding of the spectrum of bone tissue response to its muscular disuse environment in archaeological contexts, we tested whether bone histology in an individual afflicted with long-term loss of muscle function showed unremodelled primary bone due to minimal/absent, mechanical stimulation. We examined cortical bone histology in a 1906–1523 cal BC atrophied post-cranium of a young adult (mid-20s) male who had suffered from Klippel-Feil Syndrome Type III, experiencing minimally paraplegia and potentially complete or intermittent quadriplegia in late childhood/early adolescence. Samples taken from the humeral and femoral midshaft displayed thin cortices and extensive retention of primary bone with only localised Haversian tissue or isolated secondary osteons. The retention of widespread primary bone and thin cortices in this adult individual is evidence for stunted modelling and remodelling due to immobility during early ontogeny. Our bone histology descriptions should be of interest to palaeobiologists investigating the effects of physical inactivity on bone microstructure in fossilised and archaeological human remains. | |
dc.description.sponsorship | Funding for this work was received from the Australian Research Council (DE190100068 to Miszkiewicz), and the Australian National University (to Miszkiewicz and Oxenham). | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | Routledge Journals, Taylor & Francis Ltd | |
dc.rights | © 2022 The Author(s) | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Historical Biology: An International Journal of Paleobiology | |
dc.subject | palaeohistology | |
dc.subject | biomechanics | |
dc.subject | quadriplegia | |
dc.subject | bone remodelling | |
dc.subject | bone modelling | |
dc.subject | Klippel-Feil syndrome | |
dc.title | Primary bone retention in a young adult male with limb disuse: a bioarchaeological case study | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 35 | |
dcterms.dateAccepted | 2022-01-14 | |
dc.date.issued | 2022 | |
local.identifier.absfor | 430101 - Archaeological science | |
local.identifier.absfor | 440103 - Biological (physical) anthropology | |
local.identifier.ariespublication | a383154xPUB25442 | |
local.publisher.url | https://www.tandfonline.com/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Walker, Meg, College of Arts and Social Sciences, ANU | |
local.contributor.affiliation | Oxenham, Marc, College of Arts and Social Sciences, ANU | |
local.contributor.affiliation | Nguyen, Mai Huong T., Institute of Archaeology | |
local.contributor.affiliation | Trinh, Hiep Hoang, Vietnam Institute of Archaeology | |
local.contributor.affiliation | Minh, Tran Thi, Institute of Archaeology | |
local.contributor.affiliation | Nguyen, Lan Cuong, Institute of Archaeology | |
local.contributor.affiliation | Matsumura, Hirofumi, Sapporo Medical University | |
local.contributor.affiliation | Miszkiewicz, Justyna, College of Arts and Social Sciences, ANU | |
dc.relation | http://purl.org/au-research/grants/arc/DE190100068 | |
local.bibliographicCitation.issue | 2 | |
local.bibliographicCitation.startpage | 235 | |
local.bibliographicCitation.lastpage | 241 | |
local.identifier.doi | 10.1080/08912963.2022.2032027 | |
local.identifier.absseo | 280123 - Expanding knowledge in human society | |
local.identifier.absseo | 130702 - Understanding Asia’s past | |
dc.date.updated | 2023-04-30T08:15:42Z | |
dcterms.accessRights | Open Access | |
dc.provenance | This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. | |
dc.rights.license | Creative Commons Attribution-NonCommercial-NoDerivatives License | |
Collections | ANU Research Publications |
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