Restricted Semliki Forest virus replication inperforin and Fas-ligand double-deficient mice
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Alsharifi, Mohammed; Lobigs, Mario; Bettadapura, Jayaram; Koskinen, Aulikki; Mullbacher, Arno
Description
Previously, we have shown that mice defective in granule exocytosis and/ or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xg/d) relative to that in wild-type counterparts and found that viral replication in perf-/-xg/d mice is remarkably restricted. Although the mechanism...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/30513 |
Source: | Journal of General Virology |
DOI: | 10.1099/vir.0.83626-0 |
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File | Description | Size | Format | Image |
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01_Alsharifi_Restricted_Semliki_Forest_2008.pdf | 101.26 kB | Adobe PDF | Request a copy |
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