Alsharifi, Mohammed; Lobigs, Mario; Bettadapura, Jayaram; Koskinen, Aulikki; Mullbacher, Arno
Previously, we have shown that mice defective in granule exocytosis and/ or Fas.L/Fas-mediated cytolytic pathways are significantly more resistant to alphavirus, Semliki Forest virus (SFV), infection compared with wild-type mice. Here, we evaluated SFV replication in different tissues of mice defective in both cytolytic pathways (perf-/-xg/d) relative to that in wild-type counterparts and found that viral replication in perf-/-xg/d mice is remarkably restricted. Although the mechanism...[Show more]
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