Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
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Ellyard, Julia; Avery, Danielle T; Phan, Tri Giang; Hare, Nathan; Hodgkin, Phillip D; Tangye, Stuart G
Description
Plasma cells (PCs) represent the final stage of B-cell differentiation and are devoted to the production of Immunoglobulin (Ig). Perturbations to their development can result in human disorders characterized by PC expansion and hypergammaglobulinemia. Ig-secreting cells (ISCs) have been identified in secondary lymphoid tissues and bone marrow (BM). Most ISCs in lymphoid tissue are short-lived; in contrast, ISCs that migrate to the BM become long-lived PCs and continue to secrete immunoglobulin...[Show more]
Collections | ANU Research Publications |
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Date published: | 2004 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/29884 |
Source: | Blood |
DOI: | 10.1182/blood-2003-09-3109 |
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01_Ellyard_Antigen-selected,_2004.pdf | 358.73 kB | Adobe PDF | Request a copy |
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