Antigen-selected, immunoglobulin-secreting cells persist in human spleen and bone marrow
Plasma cells (PCs) represent the final stage of B-cell differentiation and are devoted to the production of Immunoglobulin (Ig). Perturbations to their development can result in human disorders characterized by PC expansion and hypergammaglobulinemia. Ig-secreting cells (ISCs) have been identified in secondary lymphoid tissues and bone marrow (BM). Most ISCs in lymphoid tissue are short-lived; in contrast, ISCs that migrate to the BM become long-lived PCs and continue to secrete immunoglobulin...[Show more]
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