Mucosal and systemic SIV-specific cytotoxic CD4(+) T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques
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Khanna, Mayank; Jackson, Ronald; Alcantara, Sheilajen; Amarasena, Thakshila H; Li, Jerry; Kelleher, Anthony D; Kent, Stephen J; Ranasinghe, Charani
Description
A HIV vaccine that provides mucosal immunity is urgently needed. We evaluated an intranasal recombinant Fowlpox virus (rFPV) priming vaccine followed by intramuscular Modified Vaccinia Ankara (rMVA) booster vaccine, both expressing SIV antigens. The vaccination generated mucosal and systemic SIV-specific CD4(+) T cell mediated immunity and was associated with partial protection against high-dose intrarectal SIVmac251 challenge in outbred pigtail macaques. Three of 12 vaccinees were completely...[Show more]
Collections | ANU Research Publications |
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Date published: | 2019 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/294693 |
Source: | Scientific Reports |
DOI: | 10.1038/s41598-019-41506-5 |
Access Rights: | Open Access |
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s41598-019-41506-5.pdf | 6.29 MB | Adobe PDF |
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