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Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

Sutton, Harry; Aye, Racheal; Idris, Azza; Vistein, Rachel; Nduati, Eunice W; Kai, Oscar; Mwacharo, Jedida; Li, Sean; Gao, Xin; Andrews, Dan; Koutsakos, Marios; Nguyen, Thi H O; Nekrasov, Maxim; Milburn, Peter; Eltahla, Auda A; Berry, Andrea A; Chakravarty, Sumana; Cockburn, Ian


The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and resting memory B cells and an alternative lineage, which includes previously described atypical B cells. Although atypical B cells have previously been associated with disease states, the alternative lineage...[Show more]

CollectionsANU Research Publications
Date published: 2021
Type: Journal article
Source: Cell Reports
DOI: 10.1016/j.celrep.2020.108684
Access Rights: Open Access


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