Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
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Sutton, Harry; Aye, Racheal; Idris, Azza; Vistein, Rachel; Nduati, Eunice W; Kai, Oscar; Mwacharo, Jedida; Li, Sean; Gao, Xin; Andrews, Dan; Koutsakos, Marios; Nguyen, Thi H O; Nekrasov, Maxim; Milburn, Peter; Eltahla, Auda A; Berry, Andrea A; Chakravarty, Sumana; Cockburn, Ian
Description
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing (RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals. This reveals two B cell lineages: a classical lineage of activated and resting memory B cells and an alternative lineage, which includes previously described atypical B cells. Although atypical B cells have previously been associated with disease states, the alternative lineage...[Show more]
Collections | ANU Research Publications |
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Date published: | 2021 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/294111 |
Source: | Cell Reports |
DOI: | 10.1016/j.celrep.2020.108684 |
Access Rights: | Open Access |
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TMP4932976572023711121814.pdf | 7.03 MB | Adobe PDF |
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