Unexpected involvement of IL-13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination
-
Altmetric Citations
Abd Hamid, Megat; Jackson, Ronald; Roy, Sreeja; Khanna, Mayank; Ranasinghe, Charani
Description
In this study, recombinant pox viral vaccination was shown to induce highly elevated IgG2a and low IgG1 antibody expression in mice lacking IL‐4 or STAT6, whilst IL‐13−/− mice exhibited elevated IgG1, but very low IgG2a. These findings revealed that IL‐13 and IL‐4 differentially regulated antibody development. To understand this further, when STAT6−/− mice were given a vaccine co‐expressing IL‐13Rα2 that temporarily sequestered IL‐13, significantly reduced IgG2a expression, was detected. These...[Show more]
Collections | ANU Research Publications |
---|---|
Date published: | 2018-03-12 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/293979 |
Source: | European Journal of Immunology |
DOI: | 10.1002/eji.201747463 |
Access Rights: | Free Access via Publisher Site |
Download
File | Description | Size | Format | Image |
---|---|---|---|---|
Eur J Immunol - 2018 - Hamid - Unexpected involvement of IL‐13 signalling via a STAT6 independent mechanism during murine.pdf | 1.41 MB | Adobe PDF | Request a copy |
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.
Updated: 17 November 2022/ Responsible Officer: University Librarian/ Page Contact: Library Systems & Web Coordinator