Effects of interleukin-6 on extravillous trophoblast invasion in early human pregnancy
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Champion, Hedele; Innes, Barbara; Robson, Stephen; Lash, Gendie; Bulmer, Judith
Description
Invasion of uterine tissues by extravillous trophoblast cells (EVT) is essential for successful human pregnancy. EVT invasion is tightly regulated by a number of factors, including growth factors and cytokines, but the mechanisms that underlie their regulatory effect remain poorly understood. Interleukin (IL)-6 has been suggested to play a role in controlling EVT invasion. We hypothesized that IL-6 produced by cells in uterine decidua would regulate EVT invasiveness via IL-6Ra and gp130...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/291323 |
Source: | Molecular Human Reproduction |
DOI: | 10.1093/molehr/gas010 |
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