Application of the Double-Mutant Cycle Strategy to Protein Aggregation Reveals Transient Interactions in Amyloid‑β Oligomers
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Das, Anirban; Korn, Alexander; Carroll, Adam; Carver, John; Maiti, Sudipta
Description
Transient oligomeric intermediates in the peptide or protein aggregation pathway are suspected to be the key toxic species in many amyloid diseases, but deciphering their molecular nature has remained a challenge. Here we show that the strategy of “double-mutant cycles”, used effectively in probing protein-folding intermediates, can reveal transient interactions during protein aggregation. It does so by comparing the changes in thermodynamic parameters between the wild type, and single and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2021 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/289378 |
Source: | Journal of Physical Chemistry B |
DOI: | 10.1021/acs.jpcb.1c05829 |
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