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Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells

Adams, Mathew M.; van Leeuwen, Barbara; McFadden, Grant; Kerr, Peter J.

Description

Deletion of the M063 gene from myxoma virus produces a virus that is unable to replicate in rabbit cells in vitro or in live rabbits but can be propagated in non-rabbit cell lines. A targeted M063 deletion mutant was constructed in the attenuated Uriarra strain of myxoma virus and the ability of this virus to act as a safe, non-transmissible vaccine against myxomatosis was tested in outbred laboratory rabbits. Immunization with the M063 deletion vaccine provided good short-term protection...[Show more]

CollectionsANU Research Publications
Date published: 2008-09-09
Type: Journal article
URI: http://hdl.handle.net/1885/28574
Source: Veterinary Research
DOI: 10.1051/vetres:2008037

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