Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells
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Adams, Mathew M.; van Leeuwen, Barbara; McFadden, Grant; Kerr, Peter J.
Description
Deletion of the M063 gene from myxoma virus produces a virus that is unable to replicate in rabbit cells in vitro or in live rabbits but can be propagated in non-rabbit cell lines. A targeted M063 deletion mutant was constructed in the attenuated Uriarra strain of myxoma virus and the ability of this virus to act as a safe, non-transmissible vaccine against myxomatosis was tested in outbred laboratory rabbits. Immunization with the M063 deletion vaccine provided good short-term protection...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008-09-09 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/28574 |
Source: | Veterinary Research |
DOI: | 10.1051/vetres:2008037 |
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01_Adams_Construction_and_testing_of_a_2008.pdf | Published Version | 620.74 kB | Adobe PDF |
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