Skip navigation
Skip navigation

Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells

Adams, Mathew M.; van Leeuwen, Barbara H.; McFadden, Grant; Kerr, Peter J.


Deletion of the M063 gene from myxoma virus produces a virus that is unable to replicate in rabbit cells in vitro or in live rabbits but can be propagated in non-rabbit cell lines. A targeted M063 deletion mutant was constructed in the attenuated Uriarra strain of myxoma virus and the ability of this virus to act as a safe, non-transmissible vaccine against myxomatosis was tested in outbred laboratory rabbits. Immunization with the M063 deletion vaccine provided good short-term protection...[Show more]

CollectionsANU Research Publications
Date published: 2008-09-09
Type: Journal article
Source: Veterinary Research
DOI: 10.1051/vetres:2008037


File Description SizeFormat Image
01_Adams_Construction_and_testing_of_a_2008.pdfPublished Version620.74 kBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator