Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease
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Denniss, A.; Dulhunty, Angela; Beard, Nicole
Description
Calcium release from internal stores is a quintessential event in excitation-contraction coupling in cardiac and skeletal muscle. The ryanodine receptor Ca2+ release channel is embedded in the internal sarcoplasmic reticulum Ca2+ store, which releases Ca2+ into the cytoplasm, enabling contraction. Ryanodine receptors form the hub of a macromolecular complex extending from the extracellular space to the sarcoplasmic reticulum lumen. Ryanodine receptor activity is influenced by the integrated...[Show more]
Collections | ANU Research Publications |
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Date published: | 2018-05-30 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/274123 |
Source: | The International Journal of Biochemistry and Cell Biology |
DOI: | 10.1016/j.biocel.2018.05.004 |
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