Candidate Biomarkers for Systematic Inflammatory Response Syndrome and Inflammation: A Pathway for Novel Translational Therapeutics
Objective: Systemic inflammatory response syndrome (SIRS) causes 200,000 deaths/year in the USA and has central nervous system (CNS) and peripheral components. Our aim was to identify candidate biomakers for SIRS and inflammation by studying the molecular pathways implicated in the CNS and the periphery, in order to facilitate translation into conceptually novel treatments. Methods: We used systemic administration of lipopolysaccharide (LPS) of Gram-negative bacteria to cause SIRS in rodents....[Show more]
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