Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study
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Hawi, Ziarih; Cummins, TDR; Tong, J; Arcos-Burgos, Mauricio; Zhao, Q; Matthews, N; Newman, Daniel P; Johnson, B; Vance, Alasdair; Heussler, HS; Levy, Florence; Easteal, Simon
Description
Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here...[Show more]
Collections | ANU Research Publications |
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Date published: | 2017 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/247705 |
Source: | Molecular Psychiatry |
DOI: | 10.1038/mp.2016.117 |
Access Rights: | Open Access |
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Rare DNA variants in the brain derived neurotrophic factor_AAM.pdf | 693.73 kB | Adobe PDF |
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