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Rare DNA variants in the brain-derived neurotrophic factor gene increase risk for attention-deficit hyperactivity disorder: a next-generation sequencing study

Hawi, Ziarih; Cummins, TDR; Tong, J; Arcos-Burgos, Mauricio; Zhao, Q; Matthews, N; Newman, Daniel P; Johnson, B; Vance, Alasdair; Heussler, HS; Levy, Florence; Easteal, Simon

Description

Attention-deficit hyperactivity disorder (ADHD) is a prevalent and highly heritable disorder of childhood with negative lifetime outcomes. Although candidate gene and genome-wide association studies have identified promising common variant signals, these explain only a fraction of the heritability of ADHD. The observation that rare structural variants confer substantial risk to psychiatric disorders suggests that rare variants might explain a portion of the missing heritability for ADHD. Here...[Show more]

CollectionsANU Research Publications
Date published: 2017
Type: Journal article
URI: http://hdl.handle.net/1885/247705
Source: Molecular Psychiatry
DOI: 10.1038/mp.2016.117
Access Rights: Open Access

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