Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature
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Paige, Ellie; Masconi, Katya; Tsimikas, Sotirios; kronenberg, Florian; Santer, Peter; Weger, Siegfried; Willeit, Johann; Kiechl, Stefan; Willeit, Peter
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AIMS: We aimed to (1) assess the association between lipoprotein(a) [Lp(a)] concentration and incident type-2 diabetes in the Bruneck study, a prospective population-based study, and (2) combine findings with evidence from published studies in a literature-based meta-analysis. METHODS: We used Cox proportional hazards models to calculate hazard ratios (HR) for incident type-2 diabetes over 20 years of follow-up in 815 participants of the Bruneck study according to their long-term average Lp(a)...[Show more]
dc.contributor.author | Paige, Ellie | |
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dc.contributor.author | Masconi, Katya | |
dc.contributor.author | Tsimikas, Sotirios | |
dc.contributor.author | kronenberg, Florian | |
dc.contributor.author | Santer, Peter | |
dc.contributor.author | Weger, Siegfried | |
dc.contributor.author | Willeit, Johann | |
dc.contributor.author | Kiechl, Stefan | |
dc.contributor.author | Willeit, Peter | |
dc.date.accessioned | 2021-08-02T00:32:32Z | |
dc.date.available | 2021-08-02T00:32:32Z | |
dc.identifier.issn | 1475-2840 | |
dc.identifier.uri | http://hdl.handle.net/1885/242578 | |
dc.description.abstract | AIMS: We aimed to (1) assess the association between lipoprotein(a) [Lp(a)] concentration and incident type-2 diabetes in the Bruneck study, a prospective population-based study, and (2) combine findings with evidence from published studies in a literature-based meta-analysis. METHODS: We used Cox proportional hazards models to calculate hazard ratios (HR) for incident type-2 diabetes over 20 years of follow-up in 815 participants of the Bruneck study according to their long-term average Lp(a) concentration. For the meta-analysis, we searched Medline, Embase and Web of Science for relevant prospective cohort studies published up to October 2016. RESULTS: In the Bruneck study, there was a 12% higher risk of type-2 diabetes for a one standard deviation lower concentration of log Lp(a) (HR = 1.12 [95% CI 0.95-1.32]; P = 0.171), after adjustment for age, sex, alcohol consumption, body mass index, smoking status, socioeconomic status, physical activity, systolic blood pressure, HDL cholesterol, log high-sensitivity C-reactive protein and waist-hip ratio. In a meta-analysis involving four prospective cohorts with a total of 74,575 participants and 4514 incident events, the risk of type-2 diabetes was higher in the lowest two quintiles of Lp(a) concentrations (weighted mean Lp(a) = 3.3 and 7.0 mg/dL, respectively) compared to the highest quintile (62.9 mg/dL), with the highest risk of type-2 diabetes seen in quintile 1 (HR = 1.28 [1.14-1.43]; P < 0.001). CONCLUSIONS: The current available evidence from prospective studies suggests that there is an inverse association between Lp(a) concentration and risk of type-2 diabetes, with a higher risk of type-2 diabetes at low Lp(a) concentrations (approximately <7 mg/dL). | |
dc.description.sponsorship | The Bruneck Study was supported by the ‘Pustertaler Verein zur Prävention von Herz- und Hirngefaesserkrankungen, Gesundheitsbezirk Bruneck’ and the ‘Assessorat für Gesundheit’, Province of Bolzano, Italy, and an excellence initiative (Competence Centers for Excellent Technologies-COMET) of the Austrian Research Promotion Agency FFG: “Research Center of Excellence in Vascular Ageing—Tyrol, VASCage” (K-Project Number 843536). Peter Willeit was supported by an Erwin-Schrödinger-Fellowship sponsored by the Austrian Science Fund (J-3679-B13). | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_AU | |
dc.publisher | BioMed Central | |
dc.rights | © The Author(s) 2017. | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Cardiovascular Diabetology | |
dc.subject | Lipoprotein(a) | |
dc.subject | Diabetes | |
dc.subject | Prospective study | |
dc.subject | Meta-analysis | |
dc.title | Lipoprotein(a) and incident type-2 diabetes: results from the prospective Bruneck study and a meta-analysis of published literature | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 16 | |
dc.date.issued | 2017 | |
local.identifier.absfor | 111706 - Epidemiology | |
local.identifier.absfor | 111711 - Health Information Systems (incl. Surveillance) | |
local.identifier.absfor | 110107 - Metabolic Medicine | |
local.identifier.ariespublication | u4102339xPUB211 | |
local.publisher.url | http://www.cardiab.com/ | |
local.type.status | Published Version | |
local.contributor.affiliation | Paige, Ellie, College of Health and Medicine, ANU | |
local.contributor.affiliation | Masconi, Katya, University of Cambridge | |
local.contributor.affiliation | Tsimikas, Sotirios, Department of Medicine, University of California San Diego | |
local.contributor.affiliation | kronenberg, Florian, Division of Genetic Epidemiology, Medical University of Innsbruck | |
local.contributor.affiliation | Santer , Peter , Department of Laboratory Medicine, Bruneck Hospital, Bruneck | |
local.contributor.affiliation | Weger , Siegfried , Department of Internal Medicine, Bruneck Hospital, Bruneck | |
local.contributor.affiliation | Willeit, Johann, Department of Neurology, Medical University of Innsbruck, Innsbruck | |
local.contributor.affiliation | Kiechl, Stefan, Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria | |
local.contributor.affiliation | Willeit, Peter , University of Cambridge | |
local.bibliographicCitation.issue | 38 | |
local.bibliographicCitation.startpage | 1 | |
local.bibliographicCitation.lastpage | 11 | |
local.identifier.doi | 10.1186/s12933-017-0520-z | |
local.identifier.absseo | 920204 - Evaluation of Health Outcomes | |
local.identifier.absseo | 920203 - Diagnostic Methods | |
local.identifier.absseo | 920104 - Diabetes | |
dc.date.updated | 2020-11-23T10:45:45Z | |
local.identifier.thomsonID | 000396943900001 | |
dcterms.accessRights | Open Access | |
dc.provenance | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/ publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |
dc.rights.license | Creative Commons Attribution 4.0 International License | |
Collections | ANU Research Publications |
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