Exploiting excess sharing: a more powerful test of linkage for affected sib pairs than the transmission/disequilibrium test
The transmission/disequilibrium test (TDT) is a popular, simple, and powerful test of linkage, which can be used to analyze data consisting of transmissions to the affected members of families with any kind pedigree structure, including affected sib pairs (ASPs). Although it is based on the preferential transmission of a particular marker allele across families, it is not a valid test of association for ASPs. Martin et al. devised a similar statistic for ASPs, T(sp), which is also based on...[Show more]
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|Source:||American Journal of Human Genetics|
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